Automated IDMS Workflows & Bioanalytics

We turn your equipment into pipetting robots (compatible with most vendor autosamplers). Nisotopes bridges stable isotope dilution mass spectrometry with automated liquid handling and turnkey ISO 17025 validation frameworks.

Nisotopes Kits™

Pre-dispensed, lyophilized isotope spike plates engineered for rapid, error-free volumetric preparation.

AutoScript™

Validated automation scripts tailored for major liquid handlers to eliminate batch-to-batch CV variance.

Qualify™ Framework

Complete regulatory and GUM uncertainty compliance packages built for early-stage biopharma & CROs.

Targeted Assay Kits

Pre-formulated stable isotope dilution mass spectrometry (IDMS) standards.

¹³C Stable Isotope Plates

High-purity isotopic spikes pre-formatted in 96-well microplate configurations with matrix barcodes.

Custom Synthesis Spike Mixes

Tailor-made internal standard mixtures synthesized to meet specialized biopharma quantitation demands.

Auto-Calibration Standards

Calibrated reference standards designed for direct integration into automated sample prep decks.

Automated Deck Integration

Seamless liquid handler protocols designed for high-throughput MS.

Turnkey Automation Protocols

Our AutoScript™ library plugs directly into modern automated liquid handlers, enabling hands-free internal standard spiking, serial dilutions, and plate preparation with minimal operator intervention.

IDMS Calibration & Quantitation Workstation

Calibrate using amount ratio n_ref / n_IS, view linear regression curves with adjustable SD/SEM error bars, and interpolate unknown samples.

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Step 1: Calibration Standards

Points sharing the same amount ratio n_ref / n_IS are averaged automatically.

Click to upload calibration standards file (.txt / .csv)

Standard ID	Amount Ratio n_ref / n_IS	Analyte Area (I_x)	IS Area (I_y)	Area Ratio (I_x / I_y)	Action

Regression Curve & Uncertainty

Error Bars:

Equation (Averaged): y = 0.0000x + 0.0000

R² Fit: 0.0000

Step 2: Unknown Samples Import

Upload a .txt or .csv file containing unknown sample peak areas (`Sample_ID, Analyte_Area, IS_Area`).

Click to upload unknown peak area file

or drag and drop text export here

Using default unknown sample set.

Unknown Sample ID	Analyte Area (I_x)	IS Area (I_y)	Area Ratio (I_x / I_y)	Interpolated Amount Ratio n_ref / n_IS

SMILES & Peptide Sequence Mass Converter

Convert structures and amino acid sequences into exact masses, formulas, adduct m/z, and 2D/3D chemical drawings.

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Amino Acid Sequence to SMILES & Mass

Enter a 1-letter peptide sequence (e.g., ACDEF, GFF) to automatically generate its SMILES string and structure.

Presets:

SMILES String & 2D/3D Structure Preview

Small Molecule Presets:

Structure Viewport

Monoisotopic Mass (Da)

180.0423

Average Mass (Da)

180.157

[M+H]+ Adduct (m/z)

181.0495

Molecular Formula

C₉H₈O₄

ISO 17025 & Regulatory Support

Qualify™ validation packages built for bioanalytical compliance.

Turnkey Audit Readiness

We provide full measurement uncertainty evaluations, GUM-compliant calculation frameworks, and ISO 17025 documentation kits to streamline your CRO or lab accreditation process.

Partner With Nisotopes

Request a custom kit synthesis or platform demo.